The Perfect Patient

Dr. Wilbur Lam and his mentee Rob Mannino sitting in front of a laboratory to discuss Rob's research

The Perfect Patient

Rob Mannino used his own chronic, life-threatening blood disorder to pursue his dream of becoming a biomedical engineer. Now he is poised to advance the field of mobile health technology.

“I was always curious about my disease,” he explains. “I always wanted to study it.”

Six years ago, as a sophomore at Georgia Tech, Mannino was able to begin studying it. A blood disease called beta thalassemia. His hematologist at Children’s Healthcare of Atlanta introduced him to a fellow physician on staff who also happened to be an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering.

Meeting a Perfect Mentor

Anemia
A reduction in the number of red blood cells, or a decreased capacity of red blood cells to carry oxygen.

Beta thalassemia
A genetically inherited form of anemia in which the beta globin protein, a main component of hemoglobin, is not adequately synthesized by the body.

At that time, he had been going to Children’s every month for almost two decades to undergo grueling blood transfusions — the only therapeutic treatment for beta thalassemia. This genetic disorder causes a reduction of hemoglobin, which is the red blood cell protein that delivers oxygen throughout the body, and it causes chronic anemia. He was diagnosed at six months old.

Meeting Wilbur Lam changed everything. Mannino began doing research in the Lam lab, and at the same time he inspired his new mentor to develop HealthReach, a program in the Coulter Department that brings undergraduates to Children’s to help pediatric patients learn about science and math by understanding their own diseases. Lam describes it as “a perfect mix. You have undergraduates applying their engineering skills to patients, and then you have patients who now have a new way to discover that there is science going on in their own bodies.”

 

Developing a Hypothesis

Mannino’s curiosity, and his passion for biomedical engineering, did not end with his graduation in 2013. He continued on as a graduate student in Lam’s lab, pursuing technological innovation in diagnostic tools as well as a Ph.D. Along the way, he began to develop a hypothesis about smartphone technology and an application that could possibly help patients to test their own hemoglobin levels by taking a picture of their fingernails.

He came up with the idea to photograph fingernails with a smartphone and compare them to the hemoglobin measured from blood draws. Still in the early stages of testing, the application of the algorithm in a mobile device will have to go through multiple clinical studies and be approved by the Food and Drug Administration before it is actually implemented.

Dr. Lam and Rob Mannino in the lab where Rob works. Rob is demonstrating taking a photo of his fingernails like a patient would when using his app. Quote from Dr. Lam: "This is nothing short of revolutionary. Envision tests that can  be done remotely,  and all you need is a phone."

“This is nothing short of revolutionary,” says Lam. “Envision tests that can be done remotely, and all you need is a phone. The capability to diagnose remotely, the capability to not require any other external equipment — that is really the potential of Rob’s work. Because he was his own test subject in the very beginning to prove that his system worked, he enabled our entire laboratory to move in a new direction. He is the perfect patient.”

Lam is part of a startup company that seeks to commercialize technologies emerging from his lab. Someday, Mannino hopes to join the company, and they both hope that this app will reach the marketplace. If successful, they will consider pursuing the application of the technology to other disorders. Lam and his team have already helped to advance smartphone technology that can check children’s ears for signs of infection. And researchers at the Georgia Tech Research Institute have developed an app that may enable people with Parkinson’s disease and other neurological conditions to collect data on hand and arm tremors.

 

Mobile Anemia Diagnosis


Rob Mannino is developing an app to indicate hemoglobin levels
 
The patient takes a photo of their fingernails

Icon of someone taking a picture of their fingernails with a smartphone

Nailbed coloration is detected and examined

Icon of a closeup of fingernails with crosshair markers where color is being examined

Algorithms analyze hemoglobin levels based on nailbed color

Icon of binary data and computer-generated graphs with data points plotted

The results are displayed and may be shared with the patient’s doctor

Icon showing a mobile phone application displaying anemia information and a doctor chat icon

Today, the only cure for beta thalassemia is a bone marrow transplant, but for Mannino it is not an option. Gene therapy holds perhaps the greatest promise for one, but for now the most effective treatment option remains regular transfusions. He wants to make things easier for those with anemia and others suffering from diseases like his — people who have to make regular trips to the hospital, which can be a major inconvenience and expense, and which involve a generally unwelcome needle stick. If this technology becomes commercialized, they would be able to download the app, monitor themselves at home, and send photographs to their doctors.  

Mannino is unflappably optimistic when he reflects on his lifelong health challenges and the journey they have inspired — a journey that was shaped in many ways by Georgia Tech’s, and the Coulter Department’s, collaborations with Children’s Healthcare of Atlanta and Emory University. “You can’t change what you’re dealing with, so use it to your advantage,” he explains. “Dealing with this disease, besides giving me motivation, has opened doors for me to do what I want to do.” 

Creating the Next

Georgia Tech is in the business of Creating the Next — the next idea, the next technology, the next legion of agile minds well equipped to imagine and engineer our future. This series of features highlights the many ways in which Georgia Tech people and their work are Creating the Next.

Beyond the Bottom Line: Georgia Tech's Economic Impact

Myavana — Shattering Startup Stereotypes

The Perfect Patient

Water, Water Everywhere

Georgia Tech's Racing Roots

Creating the Next ... Real World Solutions

CREDITS

Writer: Stacy Braukman
Digital Design: Monet Fort and Erica Endicott
Photography: Christopher Moore
Video: Troy Robinson, Micah Eavenson, Maxwell Guberman, and Adam Karcz

Published: March 22, 2017